Objective measurement of dyskinesia in Parkinson's disease using a force plate
Identifieur interne : 001B44 ( Main/Exploration ); précédent : 001B43; suivant : 001B45Objective measurement of dyskinesia in Parkinson's disease using a force plate
Auteurs : Kathryn A. Chung [États-Unis] ; Brenna M. Lobb [États-Unis] ; John G. Nutt [États-Unis] ; James Mcnames [États-Unis] ; Fay Horak [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Biomechanical Phenomena, Dyskinesia, Dyskinesia, Drug-Induced (diagnosis), Female, Force, Humans, Levodopa (adverse effects), Male, Middle Aged, Nervous system diseases, Parkinson Disease (drug therapy), Parkinson disease, Parkinson's, Postural Balance (physiology), Posture, Pressure, Psychomotor Performance, Reproducibility of Results, Severity of Illness Index, dyskinesia, force plate, objective measurements.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- diagnosis : Dyskinesia, Drug-Induced.
- drug therapy : Parkinson Disease.
- physiology : Postural Balance.
- Aged, Biomechanical Phenomena, Female, Humans, Male, Middle Aged, Posture, Pressure, Psychomotor Performance, Reproducibility of Results, Severity of Illness Index.
Abstract
Clinical investigation of levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD) is limited because of lack of objective measurements and no consensus on use of a standard measuring tool. Currently, clinical trials use subject‐completed diaries of dyskinesia throughout the day or investigator‐administered clinical rating scales. An objective and valid method of measuring LID would reduce bias, variability, and decrease the time and number needed in trials of potential anti‐dyskinetic agents. We have investigated using a force plate under standing subjects, which records movement of the center of pressure (CoP) to quantify LID over a levodopa (L‐dopa) cycle. Twenty‐two PD subjects (15 with LID, 7 without LID) admitted to an inpatient research facility had their PD meds withheld overnight, followed by a 2 hours intravenous L‐dopa infusion the next day. The root mean squared of the velocity in the anterior‐posterior direction (RMSV) derived from an analysis of the CoP, and, the modified Abnormal Involuntary Movement Scale (mAIMS) were performed repeatedly for 6 hours, initially as subjects were OFF before the infusion, through infusion until OFF again. There was a high correlation between the area under the curve (AUC) of the mAIMS and the RMSV within and between subjects. As a measure of LID, RMSV had excellent validity and reliability between subjects, and using a force plate was feasible. Sensitivity to changes in LID wasinitially demonstrated but should be repeated. Thus, CoP recordings on a force plate can objectively quantify LID in PD and may be very useful in clinical trials or other investigations of dyskinesia. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/93BC72D5AE0CBE2DA259BA5061C92B96BF5AFEA4/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148105
DOI: 10.1002/mds.22856
Affiliations:
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Le document en format XML
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Chung</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Lobb, Brenna M" sort="Lobb, Brenna M" uniqKey="Lobb B" first="Brenna M." last="Lobb">Brenna M. Lobb</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Portland VA Medical Center, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G." last="Nutt">John G. Nutt</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Mcnames, James" sort="Mcnames, James" uniqKey="Mcnames J" first="James" last="Mcnames">James Mcnames</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Electrical and Computer Engineering, Portland State University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Horak, Fay" sort="Horak, Fay" uniqKey="Horak F" first="Fay" last="Horak">Fay Horak</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15">2010-04-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="602">602</biblScope><biblScope unit="page" to="608">608</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">93BC72D5AE0CBE2DA259BA5061C92B96BF5AFEA4</idno><idno type="DOI">10.1002/mds.22856</idno><idno type="ArticleID">MDS22856</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Biomechanical Phenomena</term><term>Dyskinesia</term><term>Dyskinesia, Drug-Induced (diagnosis)</term><term>Female</term><term>Force</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson disease</term><term>Parkinson's</term><term>Postural Balance (physiology)</term><term>Posture</term><term>Pressure</term><term>Psychomotor Performance</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term><term>dyskinesia</term><term>force plate</term><term>objective measurements</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postural Balance</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Biomechanical Phenomena</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Posture</term><term>Pressure</term><term>Psychomotor Performance</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term><term>Force</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinical investigation of levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD) is limited because of lack of objective measurements and no consensus on use of a standard measuring tool. Currently, clinical trials use subject‐completed diaries of dyskinesia throughout the day or investigator‐administered clinical rating scales. An objective and valid method of measuring LID would reduce bias, variability, and decrease the time and number needed in trials of potential anti‐dyskinetic agents. We have investigated using a force plate under standing subjects, which records movement of the center of pressure (CoP) to quantify LID over a levodopa (L‐dopa) cycle. Twenty‐two PD subjects (15 with LID, 7 without LID) admitted to an inpatient research facility had their PD meds withheld overnight, followed by a 2 hours intravenous L‐dopa infusion the next day. The root mean squared of the velocity in the anterior‐posterior direction (RMSV) derived from an analysis of the CoP, and, the modified Abnormal Involuntary Movement Scale (mAIMS) were performed repeatedly for 6 hours, initially as subjects were OFF before the infusion, through infusion until OFF again. There was a high correlation between the area under the curve (AUC) of the mAIMS and the RMSV within and between subjects. As a measure of LID, RMSV had excellent validity and reliability between subjects, and using a force plate was feasible. Sensitivity to changes in LID wasinitially demonstrated but should be repeated. Thus, CoP recordings on a force plate can objectively quantify LID in PD and may be very useful in clinical trials or other investigations of dyskinesia. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Oregon</li></region></list><tree><country name="États-Unis"><region name="Oregon"><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name></region><name sortKey="Horak, Fay" sort="Horak, Fay" uniqKey="Horak F" first="Fay" last="Horak">Fay Horak</name><name sortKey="Lobb, Brenna M" sort="Lobb, Brenna M" uniqKey="Lobb B" first="Brenna M." last="Lobb">Brenna M. Lobb</name><name sortKey="Mcnames, James" sort="Mcnames, James" uniqKey="Mcnames J" first="James" last="Mcnames">James Mcnames</name><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G." last="Nutt">John G. Nutt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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